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Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

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Schulze, Markus ; Sommer, Annika ; Plötz, Sonja ; Farrell, Michaela ; Winner, Beate ; Grosch, Janina ; Winkler, Jürgen ; Riemenschneider, Markus J.
Date of publication of this fulltext: 28 Sep 2018 06:42


Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson's disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients with sporadic PD, iPSC based information on disease specific cellular phenotypes is rare. We asked whether differences may be present on genomic and epigenomic levels and performed a ...


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