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Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Schulze, Markus, Sommer, Annika, Plötz, Sonja, Farrell, Michaela, Winner, Beate, Grosch, Janina, Winkler, Jürgen and Riemenschneider, Markus J. (2018) Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs. Acta Neuropathologica Communications 6 (58), pp. 1-18.

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Date of publication of this fulltext: 28 Sep 2018 06:42

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Other URL: http://doi.org/10.1186/s40478-018-0561-x


Abstract

Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients with sporadic PD, iPSC based information on disease specific cellular phenotypes is rare. We asked whether differences may be present on genomic and epigenomic levels and performed a ...

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Item type:Article
Date:10 July 2018
Institutions:Medicine > Abteilung für Neuropathologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s40478-018-0561-xDOI
Keywords:Methylation, PD, Induced pluripotent stem cells, iPSC, SINE, LINE
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37801
Owner only: item control page

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