Schulze, Markus, Sommer, Annika, Plötz, Sonja, Farrell, Michaela, Winner, Beate, Grosch, Janina, Winkler, Jürgen and Riemenschneider, Markus J. (2018) Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs. Acta Neuropathologica Communications 6 (58), pp. 1-18.
![[img]](https://epub.uni-regensburg.de/style/images/fileicons/application_pdf.png) | License: Creative Commons Attribution 4.0 Download (5MB) |
Other URL: http://doi.org/10.1186/s40478-018-0561-x
Abstract
Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients with sporadic PD, iPSC based information on disease specific cellular phenotypes is rare. We asked whether differences may be present on genomic and epigenomic levels and performed a ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 10 July 2018 | ||||
| Institutions: | Medicine > Abteilung für Neuropathologie | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
| ||||
| Keywords: | Methylation, PD, Induced pluripotent stem cells, iPSC, SINE, LINE | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 37801 |
Download Statistics