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Drug combinations and impact of experimental conditions on relative recovery in in vitro microdialysis investigations

Burau, Daniela, Petroff, David, Simon, Philipp, Ehmann, Lisa, Weiser, Christine, Dorn, Christoph , Kratzer, Alexander, Wrigge, Hermann and Kloft, Charlotte (2018) Drug combinations and impact of experimental conditions on relative recovery in in vitro microdialysis investigations. European Journal of Pharmaceutical Sciences.

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Other URL: http://doi.org/10.1016/j.ejps.2018.10.030


Abstract

The need for pharmacokinetic knowledge about antibiotics directly at the site of infection, typically the interstitial space fluid (ISF) of tissues, is gaining acceptance for effective and safe treatment. One option to acquire such data is the microdialysis technique employing a catheter with a semipermeable membrane inserted directly in the ISF. A prerequisite is catheter calibration, e.g. via ...

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Item type:Article
Date:31 October 2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
10.1016/j.ejps.2018.10.030DOI
Keywords:Target-site sampling; Microdialysis; Relative recovery; Calibration; Influential factors; In vitro; Drug combinations
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37921
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