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Drug combinations and impact of experimental conditions on relative recovery in in vitro microdialysis investigations

Burau, Daniela ; Petroff, David ; Simon, Philipp ; Ehmann, Lisa ; Weiser, Christine ; Dorn, Christoph ; Kratzer, Alexander ; Wrigge, Hermann ; Kloft, Charlotte



Abstract

The need for pharmacokinetic knowledge about antibiotics directly at the site of infection, typically the interstitial space fluid (ISF) of tissues, is gaining acceptance for effective and safe treatment. One option to acquire such data is the microdialysis technique employing a catheter with a semipermeable membrane inserted directly in the ISF. A prerequisite is catheter calibration, e.g. via ...

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