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Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells

Renner, Kathrin, Seilbeck, Anton, Kauer, Nathalie, Ugele, Ines, Siska, Peter J., Brummer, Christina, Bruss, Christina, Decking, Sonja-Maria, Fante, Matthias, Schmidt, Astrid, Hammon, Kathrin, Singer, Katrin, Klobuch, Sebastian, Thomas, Simone, Gottfried, Eva, Peter, Katrin and Kreutz, Marina (2018) Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells. Frontiers in Pharmacology 9 (1258), pp. 1-13.

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Date of publication of this fulltext: 09 Nov 2018 07:56

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Other URL: http://doi.org/10.3389/fphar.2018.01258, https://www.frontiersin.org/articles/10.3389/fphar.2018.01258/full


Abstract

The accelerated metabolism of tumor cells, inevitable for maintaining high proliferation rates, is an emerging target for tumor therapy. Increased glucose and lipid metabolism as well as mitochondrial activity have been shown in solid tumors but also in leukemic cells. As tumor cells are able to escape the blockade of one metabolic pathway by a compensatory increase in other pathways, treatment ...

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Item type:Article
Date:2 November 2018
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fphar.2018.01258DOI
Keywords:metabolism, acute myeloid leukemia, AML, diclofenac, diflunisal, metformin, apoptosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37956
Owner only: item control page

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