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Immunmechanismen der gastrointestinalen GVHD

URN to cite this document:
urn:nbn:de:bvb:355-epub-379771
Kuhn, David
Date of publication of this fulltext: 12 Nov 2019 06:45


Abstract (German)

Im murinen fullmismatch-Modell der allogenen Knochenmarktransplantation (H2-b --> H2-d) kann nach vollständiger Rekonstitution der Spenderhämatopoese durch die selektive Eradikation von spenderstämmigen CD4+CD25+foxp3+ regulatorischen T-Zellen (Tregs) graft-versus-host-disease (GVHD) ausgelöst werden, wie durch klinische, histologische, transkriptionale (qRT-PCR) und durchflusszytometrische ...

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Translation of the abstract (English)

In the murine fullmismatch-model of allogeneic bone marrow transplantation H2-b --> H2-d GVHD ensues the selective depletion of host-derived CD4+CD25+foxp3+ regulatory T-cells (Tregs) after complete engraftment of the graft hematopoesis, as confirmed by clinical, histological, transcriptional (qRT-PCR) and flow-cytometric findings in classic GVHD target organs, predominantly in the intestine. ...

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