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Functional Characterization of the Binding Properties of the Hematopoietic Transcription Factor PU.1

URN to cite this document:
urn:nbn:de:bvb:355-epub-381262
DOI to cite this document:
10.5283/epub.38126
Minderjahn, Julia
Date of publication of this fulltext: 10 Dec 2019 06:26


Abstract (English)

Transcription factors are defined through their ability to recognize and bind specific sequence motifs in genomic DNA. Such sequence motifs are very small compared to the length of the human genome, which is why there is a large proportion of non-functional motifs, where binding of a transcription factor is undesired. The myeloid and B cell-specific transcription factor PU.1 provides a ...

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Translation of the abstract (German)

Transkriptionsfaktoren definieren sich durch ihre Fähigkeit spezifische Basenabfolgen in genomischer DNA zu erkennen und zu binden. Diese Sequenzmotive sind im Vergleich zur Länge des humanen Genoms erstaunlich klein, weshalb es für viele Transkriptionsfaktoren einen großen Anteil an nicht-funktionalen Motiven gibt, an denen ihre Bindung verhindert werden soll. Der myeloische und ...

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