Heudobler, Daniel, Rechenmacher, Michael, Lüke, Florian, Vogelhuber, Martin, Pukrop, Tobias, Herr, Wolfgang, Ghibelli, Lina, Gerner, Christopher 
and Reichle, Albrecht
(2018)
Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue.
International Journal of Molecular Sciences 19 (11), p. 3540.
| License: Creative Commons Attribution 4.0 Download (2MB) |
Other URL: http://doi.org/10.3390/ijms19113540, https://www.mdpi.com/1422-0067/19/11/3540/htm
Abstract
In most clinical trials, thiazolidinediones do not show any relevant anti-cancer activity when used as mono-therapy. Clinical inefficacy contrasts ambiguous pre-clinical data either favoring anti-tumor activity or tumor promotion. However, if thiazolidinediones are combined with additional regulatory active drugs, so-called ‘master modulators’ of tumors, i.e., transcriptional modulators, ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 9 November 2018 | ||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Keywords: | anakoinosis; communicative reprogramming; nuclear transcription factors; metronomic low-dose chemotherapy; glitazones; all-trans retinoic acid; COX-2 inhibitor; master modulators; undruggable targets; therapy pillar; peroxisome proliferator-activated receptors (PPARs); energy homeostasis; metabolic regulations; organ cross-talk; cancer and reprogramming of energy metabolism; systems biology | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 38200 |
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