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Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue

Heudobler, Daniel, Rechenmacher, Michael, Lüke, Florian, Vogelhuber, Martin, Pukrop, Tobias, Herr, Wolfgang, Ghibelli, Lina, Gerner, Christopher and Reichle, Albrecht (2018) Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue. International Journal of Molecular Sciences 19 (11), p. 3540.

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Date of publication of this fulltext: 18 Jan 2019 10:38

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Other URL: http://doi.org/10.3390/ijms19113540, https://www.mdpi.com/1422-0067/19/11/3540/htm


In most clinical trials, thiazolidinediones do not show any relevant anti-cancer activity when used as mono-therapy. Clinical inefficacy contrasts ambiguous pre-clinical data either favoring anti-tumor activity or tumor promotion. However, if thiazolidinediones are combined with additional regulatory active drugs, so-called ‘master modulators’ of tumors, i.e., transcriptional modulators, ...


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Item type:Article
Date:9 November 2018
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projects:Open Access Publizieren (DFG)
Identification Number:
Keywords:anakoinosis; communicative reprogramming; nuclear transcription factors; metronomic low-dose chemotherapy; glitazones; all-trans retinoic acid; COX-2 inhibitor; master modulators; undruggable targets; therapy pillar; peroxisome proliferator-activated receptors (PPARs); energy homeostasis; metabolic regulations; organ cross-talk; cancer and reprogramming of energy metabolism; systems biology
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38200
Owner only: item control page


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