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In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats

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Bitzinger, Diane I. ; Gruber, Michael ; Tümmler, Simon ; Malsy, Manuela ; Seyfried, Timo ; Weber, Florian ; Redel, Andreas ; Graf, Bernhard M. ; Zausig, York A.
Date of publication of this fulltext: 24 Jan 2019 09:54


Introduction. Recent studies have shown that acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may serve as important diagnostic and therapeutic targets in sepsis. Since polymorphonuclear neutrophils (PMNs) play a pivotal role in the early phase of sepsis, we evaluated the potential therapeutic effects of cholinesterase inhibitors on PMN functions during cecal ligation and puncture- ...


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