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In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats

URN to cite this document:
urn:nbn:de:bvb:355-epub-382591
DOI to cite this document:
10.5283/epub.38259
Bitzinger, Diane I. ; Gruber, Michael ; Tümmler, Simon ; Malsy, Manuela ; Seyfried, Timo ; Weber, Florian ; Redel, Andreas ; Graf, Bernhard M. ; Zausig, York A.
Date of publication of this fulltext: 24 Jan 2019 09:54


Abstract

Introduction. Recent studies have shown that acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may serve as important diagnostic and therapeutic targets in sepsis. Since polymorphonuclear neutrophils (PMNs) play a pivotal role in the early phase of sepsis, we evaluated the potential therapeutic effects of cholinesterase inhibitors on PMN functions during cecal ligation and puncture- ...

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