Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis

URN to cite this document:: urn:nbn:de:bvb:355-epub-382931
DOI to cite this document:: 10.5283/epub.38293

Schröder, Agnes ; Nazet, Ute ; Muschter, Dominique ; Grässel, Susanne

; Proff, Peter ; Kirschneck, Christian

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Date of publication of this fulltext: 04 Feb 2019 10:06

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Abstract

Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (OA-SF). We treated N-SF and OA-SF with or without mechanical loading for 48h ...