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Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis

Schröder, Agnes , Nazet, Ute, Muschter, Dominique , Grässel, Susanne , Proff, Peter and Kirschneck, Christian (2019) Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis. International Journal of Molecular Sciences 20 (3), p. 585.

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Date of publication of this fulltext: 04 Feb 2019 10:06

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Other URL: http://doi.org/10.3390/ijms20030585, https://www.mdpi.com/1422-0067/20/3/585


Abstract

Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (OA-SF). We treated N-SF and OA-SF with or without mechanical loading for 48h ...

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Item type:Article
Date:30 January 2019
Institutions:Medicine > Lehrstuhl für Kieferorthopädie
Medicine > Lehrstuhl für Orthopädie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3390/ijms20030585DOI
Keywords:osteoarthritis; synovial fibroblasts; mechanical loading; synovium; inflammation; synovitis; compressive force
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38293
Owner only: item control page

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