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Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA

Boscheinen, Jan B., Thomann, Sabrina, Knipe, David M., DeLuca, Neal, Schuler-Thurner, Beatrice, Gross, Stefanie, Dörrie, Jan, Schaft, Niels, Bach, Christian, Rohrhofer, Anette, Werner-Klein, Melanie, Schmidt, Barbara and Schuster, Philipp (2019) Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. Frontiers in Immunology 10 (2), pp. 1-13.

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Date of publication of this fulltext: 14 Feb 2019 18:00

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Other URL: http://doi.org/10.3389/fimmu.2019.00002


Abstract

Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1) d106S. To combine this innate effect with an enhanced adaptive immune response, the gene encoding human MelanA/MART-1 ...

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Item type:Article
Date:22 January 2019
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fimmu.2019.00002DOI
Keywords:vaccine, oncolytic viruses, malignant melanoma, herpes virus, cytotoxic T cell response
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38359
Owner only: item control page

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