Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA

URN to cite this document:: urn:nbn:de:bvb:355-epub-383599
DOI to cite this document:: 10.5283/epub.38359

Boscheinen, Jan B. ; Thomann, Sabrina ; Knipe, David M. ; DeLuca, Neal ; Schuler-Thurner, Beatrice ; Gross, Stefanie ; Dörrie, Jan ; Schaft, Niels ; Bach, Christian ; Rohrhofer, Anette ; Werner-Klein, Melanie ; Schmidt, Barbara ; Schuster, Philipp

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Date of publication of this fulltext: 14 Feb 2019 18:00

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Abstract

Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1) d 106S. To combine this innate effect with an enhanced adaptive immune response, the gene encoding human MelanA/MART-1 ...