Displacement of the transcription factor B reader domain during transcription initiation

URN to cite this document:: urn:nbn:de:bvb:355-epub-383983
DOI to cite this document:: 10.5283/epub.38398

Dexl, Stefan Albin ; Reichelt, Robert ; Kraatz, Katharina ; Schulz, Sarah ; Grohmann, Dina ; Bartlett, Michael ; Thomm, Michael

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Date of publication of this fulltext: 28 Feb 2019 13:34

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Abstract

Transcription initiation by archaeal RNA polymerase (RNAP) and eukaryotic RNAP II requires the general transcription factor (TF) B/IIB. Structural analyses of eukaryotic transcription initiation complexes locate the B-reader domain of TFIIB in close proximity to the active site of RNAP II. Here, we present the first crosslinking mapping data that describe the dynamic transitions of an archaeal ...