Design of functionalized b-ketoenole derivatives as efficient fluorescent dyes for detection of amyloid fibrils

URN to cite this document:: urn:nbn:de:bvb:355-epub-383996
DOI to cite this document:: 10.5283/epub.38399

Kovalska, Vladyslava ; Chernii, Svitlana

; Losytskyy, Mykhaylo

; Dovbii, Yan ; Tretyakova, Iryna ; Czerwieniec, Rafal ; Gorskii, Aleksandr

; Chernii, Victor

; Yarmoluk, Sergiy

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Date of publication of this fulltext: 01 Mar 2019 09:13

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Abstract

The self-association of proteins into insoluble filamentous aggregates - amyloid fibrils - is associated with a range of protein deposition disorders. With the aim of developing fluorescent probes sensitive to amyloid aggregates, a new series of derivatives of (2Z,5Z,7E)-6-hydroxy-2-(alkylamino)-8-arylocta-2,5,7-trien-4-one dyes was synthesized. These dyes are less sensitive to native ...