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Design of functionalized b-ketoenole derivatives as efficient fluorescent dyes for detection of amyloid fibrils

Kovalska, Vladislava , Chernii, Svitlana, Losytskyy, Mykhaylo, Dovbii, Yan, Tretyakova, Iryna, Czerwieniec, Rafal , Gorskii, Aleksandr, Chernii, Viktor and Yarmoluk, Sergiy (2018) Design of functionalized b-ketoenole derivatives as efficient fluorescent dyes for detection of amyloid fibrils. New Journal of Chemistry 42, pp. 13308-13318.

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Date of publication of this fulltext: 01 Mar 2019 09:13

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Other URL: https://pubs.rsc.org/en/Content/ArticleLanding/2018/NJ/C8NJ01020J#!divAbstract


Abstract

The self-association of proteins into insoluble filamentous aggregates – amyloid fibrils – is associated with a range of protein deposition disorders. With the aim of developing fluorescent probes sensitive to amyloid aggregates, a new series of derivatives of (2Z,5Z,7E)-6-hydroxy-2-(alkylamino)-8-arylocta-2,5,7-trien-4-one dyes was synthesized. These dyes are less sensitive to native ...

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Item type:Article
Date:12 July 2018
Institutions:Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Bernhard Dick
Identification Number:
ValueType
10.1039/c8nj01020jDOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:38399
Owner only: item control page

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