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Design of functionalized b-ketoenole derivatives as efficient fluorescent dyes for detection of amyloid fibrils

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Kovalska, Vladislava ; Chernii, Svitlana ; Losytskyy, Mykhaylo ; Dovbii, Yan ; Tretyakova, Iryna ; Czerwieniec, Rafal ; Gorskii, Aleksandr ; Chernii, Victor ; Yarmoluk, Sergiy
License: Creative Commons Attribution Non-commercial 3.0
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Date of publication of this fulltext: 01 Mar 2019 09:13


The self-association of proteins into insoluble filamentous aggregates - amyloid fibrils - is associated with a range of protein deposition disorders. With the aim of developing fluorescent probes sensitive to amyloid aggregates, a new series of derivatives of (2Z,5Z,7E)-6-hydroxy-2-(alkylamino)-8-arylocta-2,5,7-trien-4-one dyes was synthesized. These dyes are less sensitive to native ...


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