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The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer

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Malsy, Manuela ; Graf, Bernhard ; Almstedt, Katrin
Date of publication of this fulltext: 01 Mar 2019 11:29


BackgroundAdenocarcinoma of the pancreas is one of the most aggressive tumor diseases affecting the human body. The oncogenic potential of pancreatic cancer is mainly characterized by extremely rapid growth triggered by the activation of oncogenic signaling cascades, which suggests a change in the regulation of important transcription factors. Amongst others, NFAT transcription factors are ...


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