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HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women

Wege, Anja Kathrin, Chittka, Dominik, Buchholz, Stefan, Klinkhammer-Schalke, Monika, Diermeier-Daucher, Simone, Zeman, Florian, Ortmann, Olaf and Brockhoff, Gero (2018) HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women. Breast Cancer Research 20 (1), pp. 1-15.

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Date of publication of this fulltext: 01 Mar 2019 12:00

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Other URL: http://doi.org/10.1186/s13058-018-1072-1, https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1072-1#Bib1


Abstract

Background The sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. The human epidermal growth factor receptor-related receptor HER2 is known to trigger intracellular signaling cascades that modulate the activity of coregulators of the estrogen receptor which, in turn, reduces ...

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Item type:Article
Date:20 November 2018
Institutions:Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s13058-018-1072-1DOI
Keywords:HER4 receptor; Estrogen receptor positive breast cancer; Tamoxifen treatment
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38404
Owner only: item control page

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