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HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women

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Wege, Anja Kathrin ; Chittka, Dominik ; Buchholz, Stefan ; Klinkhammer-Schalke, Monika ; Diermeier-Daucher, Simone ; Zeman, Florian ; Ortmann, Olaf ; Brockhoff, Gero
Date of publication of this fulltext: 01 Mar 2019 12:00


BackgroundThe sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. The human epidermal growth factor receptor-related receptor HER2 is known to trigger intracellular signaling cascades that modulate the activity of coregulators of the estrogen receptor which, in turn, reduces ...


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