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Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study

Hartleif, Steffen, Schumm, Michael, Döring, Michaela, Mezger, Markus , Lang, Peter, Dahlke, Marc H., Riethmüller, Joachim, Königsrainer, Alfred, Handgretinger, Rupert, Nadalin, Silvio and Sturm, Ekkehard (2017) Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study. Stem Cells International 2017, pp. 1-11.

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Other URL: http://doi.org/10.1155/2017/2352954

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Background. Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. Mesenchymal stem (stromal) cells (MSC) have potent immunomodulatory properties, which may promote allograft tolerance and ameliorate toxicity of ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
10.1155/2017/2352954DOI
Keywords:REGULATORY T-CELLS; ADULT PROGENITOR CELLS; STROMAL CELLS; PHASE-I; RENAL-TRANSPLANTATION; PRETRANSPLANT INFUSION; KIDNEY-TRANSPLANTATION; ORGAN-TRANSPLANTATION; ALLOGRAFT TOLERANCE; DOPPLER ULTRASOUND;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38454
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