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Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study

Hartleif, Steffen ; Schumm, Michael ; Döring, Michaela ; Mezger, Markus ; Lang, Peter ; Dahlke, Marc H. ; Riethmüller, Joachim ; Königsrainer, Alfred ; Handgretinger, Rupert ; Nadalin, Silvio ; Sturm, Ekkehard


Background. Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. Mesenchymal stem (stromal) cells (MSC) have potent immunomodulatory properties, which may promote allograft tolerance and ameliorate toxicity of ...


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