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Polymalic Acid Tritryptophan Copolymer Interacts with Lipid Membrane Resulting in Membrane Solubilization

Ding, Hui, Fox, Irving, Patil, Rameshwar, Galstyan, Anna, Black, Keith L., Ljubimova, Julia Y. and Holler, Eggehard (2017) Polymalic Acid Tritryptophan Copolymer Interacts with Lipid Membrane Resulting in Membrane Solubilization. Journal of Nanomaterials 2017, pp. 1-11.

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Other URL: http://doi.org/10.1155/2017/4238697

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Anionic polymers with membrane permeation functionalities are highly desirable for secure cytoplasmic drug delivery. We have developed tritryptophan containing copolymer (P/WWW) of polymalic acid (PMLA) that permeates membranes by a mechanism different from previously described PMLA copolymers of trileucine (P/LLL) and leucine ethyl ester (P/LOEt) that use the "barrel stave" and "carpet" ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler
Identification Number:
ValueType
10.1155/2017/4238697DOI
Keywords:CELL-PENETRATING PEPTIDES; BREAST-CANCER-TREATMENT; LINEAR POLYETHYLENIMINE; UNILAMELLAR VESICLES; POLY(ACRYLIC ACID); TUMOR-GROWTH; POLYMERS; DELIVERY; BILAYERS; PERMEABILIZATION;
Dewey Decimal Classification:500 Science > 580 Botanical sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38464
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