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Circulating serum CK level vs. muscle impairment for in situ monitoring burden of disease in Mdx-mice

Klein, S.M. ; Prantl, L. ; Geis, S. ; Felthaus, O. ; Dolderer, J. ; Anker, A.M. ; Zeitler, K. ; Alt, E. ; Vykoukal, J.



Abstract

BACKGROUND: Duchenne muscular dystrophy (DMD) consists of a lack in the expression of the subsarcolemmal protein dystrophin causing progressive muscle dysfunction. Among the widely applied animal models in DMD research is the C57BL/1010ScSn-Dmdmdx mouse, commonly referred to as the "mdx mouse". The potential benefit of novel interventions in this model is often assessed by variables such as ...

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