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Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling

Siska, Peter J. ; Johnpulle, Romany A. N. ; Zhou, Alice ; Bordeaux, Jennifer ; Kim, Ju Young ; Dabbas, Bashar ; Dakappagari, Naveen ; Rathmell, Jeffrey C. ; Rathmell, W. Kimryn ; Morgans, Alicia K. ; Balko, Justin M. ; Johnson, Douglas B.


Platinum-based chemotherapy is usually curative for patients with testicular germ cell tumors (TGCT), but a subset of patients experience disease progression and poor clinical outcomes. Here, we tested whether immune profiling of TGCT could identify novel prognostic markers and therapeutic targets for this patient cohort. We obtained primary and metastatic TGCT samples from one center. We ...


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