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Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling

Siska, Peter J., Johnpulle, Romany A. N., Zhou, Alice, Bordeaux, Jennifer, Kim, Ju Young, Dabbas, Bashar, Dakappagari, Naveen, Rathmell, Jeffrey C., Rathmell, W. Kimryn, Morgans, Alicia K., Balko, Justin M. and Johnson, Douglas B. (2017) Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. OncoImmunology 6 (4), e1305535.

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Other URL: http://doi.org/10.1080/2162402X.2017.1305535


Abstract

Platinum-based chemotherapy is usually curative for patients with testicular germ cell tumors (TGCT), but a subset of patients experience disease progression and poor clinical outcomes. Here, we tested whether immune profiling of TGCT could identify novel prognostic markers and therapeutic targets for this patient cohort. We obtained primary and metastatic TGCT samples from one center. We ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1080/2162402X.2017.1305535DOI
Keywords:GERM-CELL TUMORS; CANCER/TESTIS ANTIGENS; IMMUNOTHERAPY; THERAPY; TISSUE; PD-1; CHEMOTHERAPY; RESISTANCE; LANDSCAPE; BLOCKADE; Immune; non-seminoma; PD-1/PD-L1; seminoma; testicular
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38469
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