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ERBB2 Expression as Potential Risk-Stratification for Early Cystectomy in Patients with pT1 Bladder Cancer and Concomitant Carcinoma in situ

Breyer, Johannes ; Otto, Wolfgang ; Wirtz, Ralph M. ; Wullich, Bernd ; Keck, Bastian ; Erben, Philipp ; Kriegmair, Maximilian C. ; Stoehr, Robert ; Eckstein, Markus ; Laible, Mark ; Schlombs, Kornelia ; Eidt, Sebastian ; Denzinger, Stefan ; Burger, Maximilian ; Hartmann, Arndt


Background/Aims/Objectives: It is difficult to identify patients with a non-muscle-invasive bladder cancer (NMIBC) at stage pT1 with concomitant carcinoma in situ (Cis) who will benefit from an early cystectomy. Methods: We retrospectively analyzed clinical data and formalin-fixed paraffin-embedded tissues of patients with NMIBC. Messenger ribonucleic acid (mRNA) expression of progesterone ...


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