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Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies

Kohl, Zacharias ; Schlachetzki, Johannes C. M. ; Feldewerth, Judith ; Hornauer, Philipp ; Münch, Martina ; Adame, Anthony ; Riemenschneider, Markus J. ; Winkler, Jürgen ; Masliah, Eliezer



Abstract

The olfactory bulb (OB) shows early neuropathological hallmarks in numerous neurodegenerative diseases, for example, in Alzheimer's disease (AD) and Parkinson's disease (PD). The glomerular and granular cell layer of the OB is characterized by preserved cellular plasticity in the adult brain. In turn, alterations of this cellular plasticity are related to neuroinflammation such as microglia ...

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