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Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma

Che, Li ; Pilo, Maria G. ; Cigliano, Antonio ; Latte, Gavinella ; Simile, Maria M. ; Ribback, Silvia ; Dombrowski, Frank ; Evert, Matthias ; Chen, Xin ; Calvisi, Diego F.



Abstract

Hepatocellular carcinoma (HCC), the most frequent primary tumor of the liver, is an aggressive cancer type with limited treatment options. Cumulating evidence underlines a crucial role of aberrant lipid biosynthesis (a process known as de novo lipogenesis) along carcinogenesis. Previous studies showed that suppression of fatty acid synthase (FASN), the major enzyme responsible for de novo ...

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