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Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma

Che, Li, Pilo, Maria G., Cigliano, Antonio , Latte, Gavinella , Simile, Maria M., Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Chen, Xin and Calvisi, Diego F. (2017) Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma. Cell Cycle 16 (6), pp. 499-507.

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Other URL: http://doi.org/10.1080/15384101.2017.1282586


Abstract

Hepatocellular carcinoma (HCC), the most frequent primary tumor of the liver, is an aggressive cancer type with limited treatment options. Cumulating evidence underlines a crucial role of aberrant lipid biosynthesis (a process known as de novo lipogenesis) along carcinogenesis. Previous studies showed that suppression of fatty acid synthase (FASN), the major enzyme responsible for de novo ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1080/15384101.2017.1282586DOI
Keywords:CANCER-CELLS; THERAPEUTIC TARGET; MOUSE MODELS; LUNG-CANCER; METABOLISM; LIVER; MICE; GROWTH; ROLES; HOMEOSTASIS; beta-catenin; AKT; c-Met; de novo lipogenesis; FASN; targeted therapies
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38484
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