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In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model

Martin, John T. ; Kim, Dong Hwa ; Milby, Andrew H. ; Pfeifer, Christian G. ; Smith, Lachlan J. ; Elliott, Dawn M. ; Smith, Harvey E. ; Mauck, Robert L.



Abstract

Total intervertebral disc replacement with a biologic engineered disc may be an alternative to spinal fusion for treating end-stage disc disease. In previous work, we developed disc-like angle ply structures (DAPS) that replicate the structure and function of the native disc and a rat tail model to evaluate DAPS in vivo. Here, we evaluated a strategy in which, after in vivo implantation, ...

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