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Transcriptomic profiling of platelet senescence and platelet extracellular vesicles

Pienimaeki-Roemer, Annika, Konovalova, Tatiana, Musri, Melina M. , Sigruener, Alexander, Boettcher, Alfred, Meister, Gunter and Schmitz, Gerd (2016) Transcriptomic profiling of platelet senescence and platelet extracellular vesicles. Transfusion 57 (1), pp. 144-156.

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Other URL: http://doi.org/10.1111/trf.13896


Abstract

BACKGROUND: Platelets (PLTs) are derived from megakaryocytes during PLT shedding. Senescent or activated PLTs are expanded in vascular and neurological diseases and release PLTextracellular vesicles (PL-EVs). A systematic analysis of regular messenger RNA (mRNA) and small RNA composition in PLTs and PL-EVs during in vitro PLT senescence has not yet been published. STUDY DESIGN AND METHODS: We ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Identification Number:
ValueType
10.1111/trf.13896DOI
Keywords:HIGH-DENSITY-LIPOPROTEIN; ALZHEIMERS-DISEASE; CIRCULATING MICRORNAS; MYOCARDIAL-INFARCTION; MESSENGER-RNA; NEURODEGENERATIVE DISEASES; COGNITIVE IMPAIRMENT; HUNTINGTONS-DISEASE; PROTEIN-PRECURSOR; ALPHA-SYNUCLEIN;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38519
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