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Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis

Pohl, Rebekka ; Haberl, Elisabeth M. ; Rein-Fischboeck, Lisa ; Zimny, Sebastian ; Neumann, Maximilian ; Aslanidis, Charalampos ; Schacherer, Doris ; Krautbauer, Sabrina ; Eisinger, Kristina ; Weiss, Thomas S. ; Buechler, Christa



Abstract

Background Chemerin is associated with insulin resistance and is expressed in the liver. Nonalcoholic fatty liver disease (NAFLD) is related to impaired insulin sensitivity, but studies evaluating hepatic and serum chemerin in NAFLD resulted in discordant data. Materials and methods Chemerin mRNA was determined in the liver tissue obtained from 33 controls and 76 NAFLD patients. Chemerin serum ...

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