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Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes

Speiseder, Thomas, Hofmann-Sieber, Helga, Rodríguez, Estefanía, Schellenberg, Anna, Akyüz, Nuray, Dierlamm, Judith, Spruss, Thilo, Lange, Claudia, Dobner, Thomas and Banks, Lawrence (2016) Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. Journal of Virology 91 (1).

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Other URL: http://doi.org/10.1128/JVI.01782-16


Abstract

Previous observations that human amniotic fluid cells (AFC) can be transformed by human adenovirus type 5 (HAdV-5) E1A/E1B oncogenes prompted us to identify the target cells in the AFC population that are susceptible to transformation. Our results demonstrate that one cell type corresponding to mesenchymal stem/stroma cells (hMSCs) can be reproducibly transformed by HAdV-5 E1A/E1B oncogenes as ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1128/JVI.01782-16DOI
Keywords:ONTOLOGY LEGO VECTORS; P53 TUMOR-SUPPRESSOR; STEM-CELLS; TRANSCRIPTIONAL REGULATION; RETINOBLASTOMA PROTEIN; TELOMERASE ACTIVITY; HUMAN CANCER; E1A; GENE; DIFFERENTIATION; DNA tumor viruses; E1A; E1B; host-virus interactions; human tumor viruses; viral transformation and carcinogenesis; hMSCs
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38527
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