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Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin

Elsterova, Jana ; Palus, Martin ; Sirmarova, Jana ; Kopecky, Jan ; Niller, Hans Helmut ; Ruzek, Daniel



Abstract

Tick-borne encephalitis (TBE) is a potentially lethal neuroinfection in humans, caused by TBE virus (TBEV). Currently, there are no approved therapeutic agents to treat TBE. Previously, it was suggested that application of high dose intravenous immunoglobulin (IVIG) may pose potentially successful treatment for severe cases of TBE. In this study, we determined the titers of TBEV-neutralizing ...

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