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Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function

Staffel, Janina, Valletta, Daniela, Federlein, Anna, Ehm, Katharina, Volkmann, Regine, Füchsl, Andrea M., Witzgall, Ralph, Kuhn, Michaela and Schweda, Frank (2016) Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function. Journal of the American Society of Nephrology 28 (1), pp. 260-277.

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Other URL: http://doi.org/10.1681/ASN.2015070731


Abstract

The cardiac natriuretic peptides (NPs), atrial NP and B-type NP, regulate fluid homeostasis and arterial BP through renal actions involving increased GFR and vascular and tubular effects. Guanylyl cyclase-A (GC-A), the transmembrane cGMP-producing receptor shared by these peptides, is expressed in different renal cell types, including podocytes, where its function is unclear. To study the effects ...

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Item type:Article
Date:2016
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda
Identification Number:
ValueType
10.1681/ASN.2015070731DOI
Keywords:CONGENITAL NEPHROTIC SYNDROME; GLOMERULAR-FILTRATION-RATE; ACETATE-SALT HYPERTENSION; CHRONIC KIDNEY-DISEASE; TRPC6 CHANNELS; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; CONSCIOUS MICE; ANGIOTENSIN-II; KNOCKOUT MICE;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38544
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