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Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function

Staffel, Janina ; Valletta, Daniela ; Federlein, Anna ; Ehm, Katharina ; Volkmann, Regine ; Füchsl, Andrea M. ; Witzgall, Ralph ; Kuhn, Michaela ; Schweda, Frank


The cardiac natriuretic peptides (NPs), atrial NP and B-type NP, regulate fluid homeostasis and arterial BP through renal actions involving increased GFR and vascular and tubular effects. Guanylyl cyclase-A (GC-A), the transmembrane cGMP-producing receptor shared by these peptides, is expressed in different renal cell types, including podocytes, where its function is unclear. To study the effects ...


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