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Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging

Kopp, Christoph, Beyer, Christian, Linz, Peter, Dahlmann, Anke, Hammon, Matthias, Jantsch, Jonathan, Neubert, Patrick, Rosenhauer, Daniela, Müller, Dominik N., Cavallaro, Alexander, Eckardt, Kai-Uwe, Schett, Georg, Luft, Friedrich C., Uder, Michael, Distler, Jörg H. W. and Titze, Jens (2016) Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging. Rheumatology 56 (4), pp. 556-560.

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Other URL: http://doi.org/10.1093/rheumatology/kew371


Abstract

Objective. Skin fibrosis is the predominant feature of SSc and arises from excessive extracellular matrix deposition. Glycosaminoglycans are macromolecules of the extracellular matrix, which facilitate Na+ accumulation in the skin. We used Na-23-MRI to quantify Na+ in skin. We hypothesized that skin Na+ might accumulate in SSc and might be a biomarker for skin fibrosis. Methods. In this ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1093/rheumatology/kew371DOI
Keywords:OSMOTICALLY INACTIVE NA+; TISSUE SODIUM; CLASSIFICATION; CRITERIA; DISEASE; STORAGE; GROWTH; systemic sclerosis; fibrosis; skin Na+; Na-23-MRI; extracellular matrix
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38565
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