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Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

Schmidt, Antje, Strecker, Jan-Kolja, Hucke, Stephanie, Bruckmann, Nils-Martin, Herold, Martin, Mack, Matthias, Diederich, Kai, Schäbitz, Wolf-Rüdiger, Wiendl, Heinz , Klotz, Luisa and Minnerup, Jens (2017) Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke. Stroke 48 (4), pp. 1061-1069.

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Other URL: http://doi.org/10.1161/STROKEAHA.116.015577


Abstract

Background and Purpose-Peripheral immune cell infiltration contributes to neural injury after ischemic stroke. However, in contrast to lymphocytes and neutrophils, the role of different monocyte/macrophage subsets remains to be clarified. Therefore, we evaluated the effects of selective and unselective monocyte/macrophage depletion and proinflammatory (M1-) and anti-inflammatory (M2-) macrophage ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
10.1161/STROKEAHA.116.015577DOI
Keywords:CEREBRAL-ARTERY OCCLUSION; ISCHEMIC BRAIN-INJURY; FUNCTIONAL RECOVERY; MICE; MACROPHAGES; ACTIVATION; MONOCYTES; CELLS; MECHANISMS; MICROGLIA; inflammation; macrophages; models; animal; monocytes; stroke
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38566
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