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Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

Schmidt, Antje ; Strecker, Jan-Kolja ; Hucke, Stephanie ; Bruckmann, Nils-Martin ; Herold, Martin ; Mack, Matthias ; Diederich, Kai ; Schäbitz, Wolf-Rüdiger ; Wiendl, Heinz ; Klotz, Luisa ; Minnerup, Jens



Abstract

Background and Purpose-Peripheral immune cell infiltration contributes to neural injury after ischemic stroke. However, in contrast to lymphocytes and neutrophils, the role of different monocyte/macrophage subsets remains to be clarified. Therefore, we evaluated the effects of selective and unselective monocyte/macrophage depletion and proinflammatory (M1-) and anti-inflammatory (M2-) macrophage ...

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