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Engineering a humanized bone organ model in mice to study bone metastases

Martine, Laure C. ; Holzapfel, Boris M. ; McGovern, Jacqui A. ; Wagner, Ferdinand ; Quent, Verena M. ; Hesami, Parisa ; Wunner, Felix M. ; Vaquette, Cedryck ; De-Juan-Pardo, Elena M. ; Brown, Toby D. ; Nowlan, Bianca ; Wu, Dan Jing ; Hutmacher, Cosmo Orlando ; Moi, Davide ; Oussenko, Tatiana ; Piccinini, Elia ; Zandstra, Peter W. ; Mazzieri, Roberta ; Lévesque, Jean-Pierre ; Dalton, Paul D. ; Taubenberger, Anna V. ; Hutmacher, Dietmar W.


Current in vivo models for investigating human primary bone tumors and cancer metastasis to the bone rely on the injection of human cancer cells into the mouse skeleton. This approach does not mimic species-specific mechanisms occurring in human diseases and may preclude successful clinical translation. We have developed a protocol to engineer humanized bone within immunodeficient hosts, which ...


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