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Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo

Asare, Yaw ; Ommer, Miriam ; Azombo, Florence. A. ; Alampour-Rajabi, Setareh ; Sternkopf, Marieke ; Sanati, Maryam ; Gijbels, Marion J. ; Schmitz, Corinna ; Sinitski, Dzmitry ; Tilstam, Pathricia V. ; Lue, Hongqi ; Gessner, André ; Lange, Denise ; Schmid, Johannes A. ; Weber, Christian ; Dichgans, Martin ; Jankowski, Joachim ; Pardi, Ruggero ; de Winther, Menno P. J. ; Noels, Heidi ; Bernhagen, Jürgen



Abstract

Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neural precursor cell-expressed, developmentally down-regulated 8 (NEDD8) moieties from cullins (thus termed "deNEDDylase") and a subunit of the cullin-RING E3 ligase-regulating COP9 signalosome complex, attenuates proinflammatory NF-kappa B signaling. We previously showed that CSN5 is up-regulated in ...

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