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Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes

Nayak, Arnab ; Reck, Anja ; Morsczeck, Christian ; Müller, Stefan



Abstract

Background: Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that the SUMO isopeptidase SENP3 regulates chromatin assembly of the MLL1/2 histone methyltransferase complex at distinct HOX genes, including the osteogenic master regulator DLX3. A ...

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