Go to content
UR Home

Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy

Hofhuis, Julia, Bersch, Kristina, Büssenschütt, Ronja, Drzymalski, Marzena, Liebetanz, David, Nikolaev, Viacheslav O., Wagner, Stefan, Maier, Lars S., Gärtner, Jutta, Klinge, Lars and Thoms, Sven (2017) Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy. Journal of Cell Science 130 (5), pp. 841-852.

Full text not available from this repository.

at publisher (via DOI)

Other URL: http://doi.org/10.1242/jcs.198861


The multi-C2 domain protein dysferlin localizes to the plasma membrane and the T-tubule system in skeletal muscle; however, its physiological mode of action is unknown. Mutations in the DYSF gene lead to autosomal recessive limb-girdle muscular dystrophy type 2B and Miyoshi myopathy. Here, we show that dysferlin has membrane tubulating capacity and that it shapes the T-tubule system. Dysferlin ...


Export bibliographical data

Item type:Article
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
Keywords:SKELETAL-MUSCLE FIBERS; C2 DOMAINS REVEALS; CENTRONUCLEAR MYOPATHY; AMPHIPHYSIN-2 BIN1; TRANSVERSE TUBULES; BINDING-PROPERTIES; REPAIR; PHOSPHOINOSITIDES; SARCOLEMMA; MUTATIONS; Dysferlin; T-tubule system; Muscular dystrophy; Dysferlinopathy; Phosphatidylinositol 4, 5-bisphosphate; C2 domain protein; Limb-girdle; muscular dystrophy type 2B; Miyoshi myopathy
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38628
Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons