In stage pT1 non-muscle-invasive bladder cancer (NMIBC), high KRT20 and low KRT5 mRNA expression identify the luminal subtype and predict recurrence and survival

Breyer, Johannes ; Wirtz, Ralph M. ; Otto, Wolfgang ; Erben, Philipp ; Kriegmair, Maximilian C. ; Stoehr, Robert ; Eckstein, Markus ; Eidt, Sebastian ; Denzinger, Stefan ; Burger, Maximilian ; Hartmann, Arndt

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Abstract

Differential expression of cytokeratins (CK) is a characteristic feature of chemoresistant luminal (KRT20) and chemosensitive intrinsic aggressive basal (KRT5) subtypes in muscle-invasive bladder cancer (MIBC). We investigated mRNA expression of KRT5 and KRT20 and its predictive value in stage pT1 bladder cancer. In retrospective analysis of clinical data and formalin-fixed paraffin-embedded ...

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