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In stage pT1 non-muscle-invasive bladder cancer (NMIBC), high KRT20 and low KRT5 mRNA expression identify the luminal subtype and predict recurrence and survival

Breyer, Johannes, Wirtz, Ralph M., Otto, Wolfgang, Erben, Philipp, Kriegmair, Maximilian C., Stoehr, Robert, Eckstein, Markus, Eidt, Sebastian, Denzinger, Stefan, Burger, Maximilian and Hartmann, Arndt (2017) In stage pT1 non-muscle-invasive bladder cancer (NMIBC), high KRT20 and low KRT5 mRNA expression identify the luminal subtype and predict recurrence and survival. Virchows Archiv 470 (3), pp. 267-274.

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Other URL: http://doi.org/10.1007/s00428-017-2064-8


Abstract

Differential expression of cytokeratins (CK) is a characteristic feature of chemoresistant luminal (KRT20) and chemosensitive intrinsic aggressive basal (KRT5) subtypes in muscle-invasive bladder cancer (MIBC). We investigated mRNA expression of KRT5 and KRT20 and its predictive value in stage pT1 bladder cancer. In retrospective analysis of clinical data and formalin-fixed paraffin-embedded ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Urologie
Identification Number:
ValueType
10.1007/s00428-017-2064-8DOI
Keywords:TRANSITIONAL-CELL-CARCINOMA; UROTHELIAL CARCINOMA; MOLECULAR TAXONOMY; PERIPHERAL-BLOOD; CYTOKERATIN-20; GRADE; BIOMARKERS; BASAL; ASSAY; KRT5; KRT20; Cytokeratin; Molecular subtypes; mRNA; NMIBC
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38636
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