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Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes

Hartmann, Nico ; Pabel, Steffen ; Herting, Jonas ; Schatter, Felix ; Renner, André ; Gummert, Jan ; Schotola, Hanna ; Danner, Bernhard C. ; Maier, Lars S. ; Frey, Norbert ; Hasenfuss, Gerd ; Fischer, Thomas H. ; Sossalla, Samuel


BACKGROUND Cardiac type 2 ryanodine receptors (RyR(2)s) Play a pivotal role in cellular electrophysiology and contractility. Increased RyR(2)-mediated diastolic sarcoplasmic reticulum (SR) Ca2+ release is linked to heart failure (HF) and arrhythmias. Dantrolene, a drug used for the treatment of malignant hyperthermia, is known to stabilize RyRs in skeletal muscle. OBJECTIVE The purpose of this ...


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