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Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes

Hartmann, Nico, Pabel, Steffen, Herting, Jonas, Schatter, Felix, Renner, André, Gummert, Jan, Schotola, Hanna, Danner, Bernhard C., Maier, Lars S., Frey, Norbert, Hasenfuss, Gerd, Fischer, Thomas H. and Sossalla, Samuel (2017) Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes. Heart Rhythm 14 (3), pp. 412-419.

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Other URL: http://doi.org/10.1016/j.hrthm.2016.09.014


Abstract

BACKGROUND Cardiac type 2 ryanodine receptors (RyR(2)s) Play a pivotal role in cellular electrophysiology and contractility. Increased RyR(2)-mediated diastolic sarcoplasmic reticulum (SR) Ca2+ release is linked to heart failure (HF) and arrhythmias. Dantrolene, a drug used for the treatment of malignant hyperthermia, is known to stabilize RyRs in skeletal muscle. OBJECTIVE The purpose of this ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1016/j.hrthm.2016.09.014DOI
Keywords:POLYMORPHIC VENTRICULAR-TACHYCARDIA; RETICULUM CA2+ LEAK; PROTEIN-KINASE-II; RYANODINE RECEPTOR; MALIGNANT HYPERTHERMIA; SARCOPLASMIC-RETICULUM; ATRIAL-FIBRILLATION; HEART-FAILURE; DELAYED AFTERDEPOLARIZATIONS; INTERDOMAIN INTERACTIONS; Dantrolene; Sarcoplasmic reticulum Ca2+ leak; Arrhythmia; Atrial fibrillation; Heart failure; Ryanodine receptor; Electrophysiology; Antiarrhythmic agent
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38640
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