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Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide

Hu, Zhongshuang ; Murakami, Taisuke ; Tamura, Hiroshi ; Reich, Johannes ; Kuwahara-Arai, Kyoko ; Iba, Toshiaki ; Tabe, Yoko ; Nagaoka, Isao


Upon exposure to invading microorganisms, neutrophils undergo NETosis, a recently identified type of programmed cell death, and release neutrophil extracellular traps (NETs). NETs are described as an antimicrobial mechanism, based on the fact that NEls can trap microorganisms and exhibit bactericidal activity through the action of NET-associated components. In contrast, the components of NETs ...


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