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WHO 1973 grade 3 and infiltrative growth pattern proved, aberrant E-cadherin expression tends to be of predictive value for progression in a series of stage T1 high-grade bladder cancer after organ-sparing approach

Otto, Wolfgang ; Breyer, Johannes ; Herdegen, Sonja ; Eder, Fabian ; Bertz, Simone ; May, Matthias ; Mayr, Roman ; Lausenmeyer, Eva M. ; Denzinger, Stefan ; van Rhijn, Bas W. G. ; Burger, Maximilian ; Hartmann, Arndt



Abstract

Stage pT1 urothelial bladder cancer (UBC) is characterized as a challenging subentity of urothelial carcinoma with an unforeseeable clinical course. In addition to more or less established clinical and histopathological features, we evaluated the role of epithelial-mesenchymal transition (EMT) marker E-cadherin, shown to be of prognostic value in muscle-invasive disease, regarding the prognosis ...

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