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Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study

Parsa, Afshin ; Kanetsky, Peter A. ; Xiao, Rui ; Gupta, Jayanta ; Mitra, Nandita ; Limou, Sophie ; Xie, Dawei ; Xu, Huichun ; Anderson, Amanda Hyre ; Ojo, Akinlolu ; Kusek, John W. ; Lora, Claudia M. ; Hamm, L. Lee ; He, Jiang ; Sandholm, Niina ; Jeff, Janina ; Raj, Dominic E. ; Böger, Carsten A. ; Bottinger, Erwin ; Salimi, Shabnam ; Parekh, Rulan S. ; Adler, Sharon G. ; Langefeld, Carl D. ; Bowden, Donald W. ; Groop, Per-Henrik ; Forsblom, Carol ; Freedman, Barry I. ; Lipkowitz, Michael ; Fox, Caroline S. ; Winkler, Cheryl A. ; Feldman, Harold I.


The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We ...


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