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The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation

Weissinger, E. M. ; Human, C. ; Metzger, J. ; Hambach, L. ; Wolf, D. ; Greinix, H. T. ; Dickinson, A. M. ; Mullen, W. ; Jonigk, D. ; Kuzmina, Z. ; Kreipe, H. ; Schweier, P. ; Böhm, O. ; Türüchanow, I. ; Ihlenburg-Schwarz, D. ; Raad, J. ; Durban, A. ; Schiemann, M. ; Könecke, C. ; Diedrich, H. ; Holler, E. ; Beutel, G. ; Krauter, J. ; Ganser, A. ; Stadler, M.



Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be curative, but is associated with significant morbidity and mortality. Chronic graft-versus-host disease (cGvHD), characterized by inflammation and fibrosis of multiple target organs, considerably contributes to the morbidity and mortality even years after allo-HSCT. Diagnosis of cGvHD is based on clinical features and histology ...

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