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The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation

Weissinger, E M ; Human, C ; Metzger, J ; Hambach, L ; Wolf, D ; Greinix, H T ; Dickinson, A M ; Mullen, W ; Jonigk, D ; Kuzmina, Z ; Kreipe, H ; Schweier, P ; Böhm, O ; Türüchanow, I ; Ihlenburg-Schwarz, D ; Raad, J ; Durban, A ; Schiemann, M ; Könecke, C ; Diedrich, H ; Holler, E ; Beutel, G ; Krauter, J ; Ganser, A ; Stadler, M



Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be curative, but is associated with significant morbidity and mortality. Chronic graft-versus-host disease (cGvHD), characterized by inflammation and fibrosis of multiple target organs, considerably contributes to the morbidity and mortality even years after allo-HSCT. Diagnosis of cGvHD is based on clinical features and histology ...

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