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Periosteum tissue engineering in an orthotopic in vivo platform

Baldwin, J. G. ; Wagner, F. ; Martine, L. C. ; Holzapfel, B. M. ; Theodoropoulos, C. ; Bas, O. ; Savi, F. . ; Werner, C. ; De-Juan-Pardo, E. M. ; Hutmacher, D. W.


The periosteum plays a critical role in bone homeostasis and regeneration. It contains a vascular component that provides vital blood supply to the cortical bone and an osteogenic niche that acts as a source of bone-forming cells. Periosteal grafts have shown promise in the regeneration of critical size defects, however their limited availability restricts their widespread clinical application. ...


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