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A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes

Joseph, Sarah, Quinn, Killian, Greenwood, Aldona, Cope, Alethea V., McKay, Paul F. , Hayes, Peter J., Kopycinski, Jakub T., Gilmour, Jill, Miller, Aleisha N., Geldmacher, Christof, Nadai, Yuka, Ahmed, Mohamed I. M., Montefiori, David C., Dally, Len, Bouliotis, George, Lewis, David J. M., Tatoud, Roger, Wagner, Ralf, Esteban, Mariano, Shattock, Robin J., McCormack, Sheena and Weber, Jonathan (2017) A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes. Frontiers in Immunology 8.

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Other URL: http://doi.org/10.3389/fimmu.2017.00149

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

There remains an urgent need for a prophylactic HIV vaccine. We compared combined MVA and adjuvanted gp140 to sequential MVA/gp140 after DNA priming. We expected Env-specific CD4+ T-cells after DNA and MVA priming, and Env-binding antibodies in 100% individuals after boosting with gp140 and that combined vaccines would not compromise safety and might augment immunogenicity. Forty volunteers were ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.3389/fimmu.2017.00149DOI
Keywords:T-CELL RESPONSES; EFFICACY TRIAL; DENDRITIC CELLS; VIRUS ANKARA; DOUBLE-BLIND; NONHUMAN-PRIMATES; CLINICAL-TRIALS; PROTEIN BOOST; CLADE-C; IMMUNOGENICITY; HIV vaccine; phase I trial; DNA; MVA; envelope protein
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38691
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