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A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes

Joseph, Sarah ; Quinn, Killian ; Greenwood, Aldona ; Cope, Alethea V. ; McKay, Paul F. ; Hayes, Peter J. ; Kopycinski, Jakub T. ; Gilmour, Jill ; Miller, Aleisha N. ; Geldmacher, Christof ; Nadai, Yuka ; Ahmed, Mohamed I. M. ; Montefiori, David C. ; Dally, Len ; Bouliotis, George ; Lewis, David J. M. ; Tatoud, Roger ; Wagner, Ralf ; Esteban, Mariano ; Shattock, Robin J. ; McCormack, Sheena ; Weber, Jonathan


There remains an urgent need for a prophylactic HIV vaccine. We compared combined MVA and adjuvanted gp140 to sequential MVA/gp140 after DNA priming. We expected Env-specific CD4+ T-cells after DNA and MVA priming, and Env-binding antibodies in 100% individuals after boosting with gp140 and that combined vaccines would not compromise safety and might augment immunogenicity. Forty volunteers were ...


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