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Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation <i>in vitro</i> and in mice

Sommer, Judith, Mahli, Abdo , Freese, Kim, Schiergens, Tobias S., Kuecuekoktay, Fulya Suzan, Teufel, Andreas, Thasler, Wolfgang E., Müller, Martina, Bosserhoff, Anja K. and Hellerbrand, Claus (2017) Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation <i>in vitro</i> and in mice. Oncotarget 8 (8).

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Other URL: http://doi.org/10.18632/oncotarget.14371


Abstract

Chemotherapy-associated steatohepatitis is attracting increasing attention because it heralds an increased risk of morbidity and mortality in patients undergoing surgery because of liver metastases. The aim of this study was to develop in vitro and in vivo models to analyze the pathogenesis of 5-fluorouracil (5-FU)-induced steatohepatitis. Therefore, primary human hepatocytes and HepG2 hepatoma ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.18632/oncotarget.14371DOI
Keywords:FATTY LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA CELLS; CHEMOTHERAPY-ASSOCIATED HEPATOTOXICITY; HEPATIC COLORECTAL METASTASES; ANTICANCER DRUGS; BETA-OXIDATION; STELLATE CELLS; CANCER-CELLS; C-JUN; STEATOHEPATITIS; 5-FU; steatosis; steatohepatitis; mitochondrial dysfunction
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38692
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