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A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis

Hähnel, Viola, Dormann, Frauke, Nitsopoulos, Athanasios, Friedle, Albrecht and Ahrens, Norbert (2017) A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis. Photochemical & Photobiological Sciences 16 (2), pp. 193-200.

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Other URL: http://doi.org/10.1039/c6pp00327c


Abstract

Background: Extracorporeal photopheresis (ECP) is an efficient method to treat various autoimmune diseases, cutaneous T-cell lymphoma, and graft-versus-host disease. It is based on the ex vivo inactivation of lymphocytes by 8-methoxypsoralen (8-MOP)/UV light treatment. Despite the adhesive, lipophilic nature of 8-MOP, no quality control is established for the ECP procedure. Methods: We developed ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
ValueType
10.1039/c6pp00327cDOI
Keywords:PHOTOCHEMOTHERAPY; PHARMACOKINETICS; PHOTOCHEMISTRY; CHROMATOGRAPHY; PROLIFERATION; PSORALENS; KINETICS; CELLS; UVA; MS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38734
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