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The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events

Sørensen, Brian B. ; Ehrnsberger, Hans F. ; Esposito, Silvia ; Pfab, Alexander ; Bruckmann, Astrid ; Hauptmann, Judith ; Meister, Gunter ; Merkl, Rainer ; Schubert, Thomas ; Längst, Gernot ; Melzer, Michael ; Grasser, Marion ; Grasser, Klaus D.



Abstract

We identify proteins that associate with the THO core complex, and show that the TEX1 and MOS11 components functionally interact, affecting mRNA export and splicing as well as plant development. TREX (TRanscription-EXport) is a multiprotein complex that plays a central role in the coordination of synthesis, processing and nuclear export of mRNAs. Using targeted proteomics, we identified proteins ...

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