Go to content
UR Home

HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation

Herr, W, Eichinger, Y, Beshay, J, Bloetz, A, Vatter, S, Mirbeth, C, Distler, E, Hartwig, U F and Thomas, S (2017) HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation. Leukemia 31 (2), pp. 434-445.

Full text not available from this repository.

at publisher (via DOI)

Other URL: http://doi.org/10.1038/leu.2016.210


Abstract

Refractory or relapsed acute myeloid leukemia (AML) represents a frequent complication after allogeneic hematopoietic stem-cell transplantation (HSCT). We show herein that primary in vitro stimulation of CD45RA-selected CD4 T cells of stem-cell donors with 10/10 HLA-matched AML blasts results in expansion of cytolytic T-lymphocytes (CTL) that almost all recognize HLA-DPB1 mismatch alleles, which ...

plus


Export bibliographical data



Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI)
Identification Number:
ValueType
10.1038/leu.2016.210DOI
Keywords:VERSUS-HOST-DISEASE; MINOR HISTOCOMPATIBILITY ANTIGENS; UNRELATED-DONOR; HLA-DP; RELAPSED LEUKEMIA; IN-VITRO; MARROW TRANSPLANTATION; LYMPHOCYTE INFUSION; ANTITUMOR IMMUNITY; ENDOTHELIAL-CELLS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38763
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons