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Death receptor 3 mediates necroptotic cell death

Bittner, Sebastian ; Knoll, Gertrud ; Ehrenschwender, Martin



Abstract

Death receptor 3 (DR3) was initially identified as a T cell co-stimulatory and pro-inflammatory molecule, but further studies revealed a more complex role of DR3 and its ligand TL1A. Although being a death receptor, DR3 gained to date predominantly attention as a contributor to inflammation-driven diseases. In our study, we investigated the cell death pathways associated with DR3. We show that in ...

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