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Correlation of the venous angioarchitecture of multiple cerebral cavernous malformations with familial or sporadic disease: a susceptibility-weighted imaging study with 7-Tesla MRI

Dammann, Philipp ; Wrede, Karsten ; Zhu, Yuan ; Matsushige, Toshinori ; Maderwald, Stefan ; Umutlu, Lale ; Quick, Harald H. ; Hehr, Ute ; Rath, Matthias ; Ladd, Mark E. ; Felbor, Ute ; Sure, Ulrich



Abstract

OBJECTIVE Multiple cerebral cavernous malformations (CCMs) are rare lesions that occur in sporadic or familial form. Depending on the disease form, the natural history and treatment of the lesions strongly vary. Molecular analysis of an underlying germline mutation (CCM1-3) is the most sensitive screening method to distinguish between sporadic and familial cases. However, based on the different ...

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