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Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine

Eisner, Christoph, Kim, SooMi, Grill, Alexandra, Qin, Yan, Hoerl, Marion, Briggs, Josephine, Castrop, Hayo, Thiel, Manfred and Schnermann, Jurgen (2017) Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine. Pflügers Archiv - European Journal of Physiology 469 (2), pp. 339-347.

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Other URL: http://doi.org/10.1007/s00424-016-1925-3


Abstract

Administration of the nucleoside adenosine has been shown to induce hypothermia in a number of species, an effect mediated predominantly by the adenosine 1 receptor (A1AR) subtype. The present experiments were performed to explore the possibility that the rise of intracellular adenosine levels expected to accompany adenosine administration may contribute to the hypothermic effect of adenosine ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie
Identification Number:
ValueType
10.1007/s00424-016-1925-3DOI
Keywords:CYTOCHROME-C-OXIDASE; PROTEIN-SYNTHESIS; SPINAL-CORD; RATS; RELEASE; HYPERALGESIA; HEPATOCYTES; INVOLVEMENT; PERFORMANCE; ORGANISMS; Mice; Adenosine; Nucleotides; Hypothermia; Adenosine kinase
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38782
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