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Altered immune reconstitution of B and T cells precedes the onset of clinical symptoms of chronic graft-versus-host disease and is influenced by the type of onset

Bohmann, E.-M., Fehn, U., Holler, B., Weber, D., Holler, E., Herr, W., Hoffmann, P., Edinger, M. and Wolff, D. (2017) Altered immune reconstitution of B and T cells precedes the onset of clinical symptoms of chronic graft-versus-host disease and is influenced by the type of onset. Annals of Hematology 96 (2), pp. 299-310.

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Other URL: http://doi.org/10.1007/s00277-016-2881-x


Abstract

We analyzed lymphocyte subpopulations and cytokines 3 months after allogeneic hematopoietic stem cell transplantation aiming to identify predictive cellular and serum markers for chronic graft-versus-host disease (cGVHD). Samples of 49 patients (pts) (no cGVHD (n = 14), subsequent quiescent onset (n = 16), de novo onset of cGVHD (n = 19)) were analyzed in the absence of active GVHD by flow ...

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Item type:Article
Date:2017
Institutions:Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI)
Identification Number:
ValueType
10.1007/s00277-016-2881-xDOI
Keywords:BONE-MARROW-TRANSPLANTATION; CHRONIC GVHD; RISK; ASSOCIATION; DEFICIENCY; DIAGNOSIS; RESPONSES; CORRELATE; RECOVERY; SURVIVAL; Allogeneic hematopoietic stem cell transplantation; Graft-versus-host disease; Bone marrow transplantation; BAFF; Immature B cells
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38783
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