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Functional impairment of CMV-reactive cellular immunity during pregnancy

Reuschel, Edith ; Barabas, Sascha ; Zeman, Florian ; Bendfeldt, Hanna ; Rascle, Anne ; Deml, Ludwig ; Seelbach-Goebel, Birgit


Cytomegalovirus (CMV) is the most common congenital viral infection. Mother-to-child transmission can cause severe child disability. Intact CMV-specific cell-mediated immunity (CMI) was shown to prevent uncontrolled replication in healthy individuals. This study aimed to determine whether CMV-specific CMI is impaired in pregnant women, thus potentially increasing the overall risk for active CMV ...


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