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Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

Leidgens, Verena, Proske, Judith, Rauer, Lisa, Moeckel, Sylvia, Renner, Kathrin, Bogdahn, Ulrich, Riemenschneider, Markus J., Proescholdt, Martin, Vollmann-Zwerenz, Arabel, Hau, Peter and Seliger, Corinna (2017) Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Oncotarget 8 (5).

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Other URL: http://doi.org/10.18632/oncotarget.14159


Abstract

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor and associated with a devastating prognosis. Signal transducer and activator of transcription number 3 (STAT3) is an important pathogenic factor in GBM and can be specifically inhibited with Stattic. Metformin inhibits GBM cell proliferation and migration. Evidence from other tumor models suggests that metformin ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
10.18632/oncotarget.14159DOI
Keywords:CANCER STEM-CELLS; HEPATIC INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; HUMAN GLIOBLASTOMA; IN-VITRO; SIGNALING PATHWAYS; BREAST-CANCER; GROWTH; AMPK; TRANSFORMATION; glioma; BTIC; STAT3; Stattic; metformin
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38794
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