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Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

Leidgens, Verena ; Proske, Judith ; Rauer, Lisa ; Moeckel, Sylvia ; Renner, Kathrin ; Bogdahn, Ulrich ; Riemenschneider, Markus J. ; Proescholdt, Martin ; Vollmann-Zwerenz, Arabel ; Hau, Peter ; Seliger, Corinna



Abstract

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor and associated with a devastating prognosis. Signal transducer and activator of transcription number 3 (STAT3) is an important pathogenic factor in GBM and can be specifically inhibited with Stattic. Metformin inhibits GBM cell proliferation and migration. Evidence from other tumor models suggests that metformin ...

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